Metabolic Instruction of Immunity

Publication date: 4 May 2017
Source:Cell, Volume 169, Issue 4
Author(s): Michael D. Buck, Ryan T. Sowell, Susan M. Kaech, Erika L. Pearce
Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.

Teaser

Immune cells are exposed to distinct environments and nutrients that influence metabolism that, in turn, instruct their effector functions, differentiation, and gene expression.


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