Abstract
Purpose of Review
Hepatitis E virus (HEV) infections are a global public health problem. These viruses were originally identified as the cause of large waterborne outbreaks with increased mortality in pregnant women in developing countries in Asia and Africa in 1983. A decade later, locally acquired cases of acute hepatitis were reported in industrialized countries after food-borne transmission from an animal reservoir, especially swine, wild boar, and deer. However, the knowledge about the clinical features of HEV infection, the animal reservoirs, and virus characteristics has expanded substantially in recent years.
Recent Findings
HEV infections in patients who are immunosuppressed after a solid organ transplant and AIDS or cancer chemotherapy frequently develop chronic hepatitis. Some patients with chronic HEV infection develop extra-hepatic manifestations, especially neurologic symptoms. Clinical observations support the effectiveness of ribavirin therapy from chronic HEV. Recent research has found an expanded animal reservoir of Hepeviridae that are human pathogens and strains that are only animal pathogens. A consensus classification of Hepeviridae has been published recently. The risk of transfusion transmission of HEV has been quantified and selected donor screening implemented in two countries in the last few years.
Summary
Recent research has greatly expanded scientific information on the diversity and zoonotic reservoirs of Hepeviridae as well as the epidemiology and clinical features of HEV infection in humans.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pSgYFB
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου