The increased rate of glycolysis and reduced oxidative metabolism are the principal biochemical phenotypes observed in pancreatic ductal adenocarcinoma (PDAC) that lead to the development of an acidic tumor microenvironment. The pH of most epithelial cell-derived tumors is reported to be lower than that of plasma. However, little is known regarding the physiology and metabolism of cancer cells enduring chronic acidosis. Here, we cultured PDAC cells in chronic acidosis (pH 6.9∼7.0) and observed that cells cultured in low pH had reduced clonogenic capacity.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2qclgnE
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Background. Reconstruction of surgical defects following cranial base surgery is challenging. Others have demonstrated that leukocyte-platel...
-
During lytic infection, herpes simplex virus (HSV) DNA is replicated by a mechanism involving DNA recombination. For instance, replication o...
-
Outcomes of multimodal management for sinonasal squamous cell carcinoma. J Craniomaxillofac Surg. 2017 May 12;: Authors: Paré A, Blan...
-
Abstract Purpose Low back pain is a significant problem for school-aged athletes. Although some risk factors relating to sports activiti...
-
Thyroid cancer is the most common malignant tumor of the endocrine system and the incidence has been increasing in recent years. In a great ...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου