Characterization of Thyroid Nodules by 4-Dimensional Computed Tomography: Initial Experience.

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Characterization of Thyroid Nodules by 4-Dimensional Computed Tomography: Initial Experience.

J Comput Assist Tomogr. 2017 Mar/Apr;41(2):195-198

Authors: Fitzgerald RT, Kuruva M, David R, Samant RS, Kumar M, Van Hemert R, Angtuaco EJ, Bodenner D, Stack BC

Abstract
OBJECTIVE: We aimed to evaluate the use of 4-dimensional computed tomography (4DCT) for characterization of thyroid nodules.
METHODS: Our study drew from 100 consecutive patients with primary hyperparathyroidism who underwent 4D parathyroid CT imaging for adenoma localization. Included subjects had tissue sampling of a thyroid nodule within 3 months of 4DCT.
RESULTS: Twenty subjects (18 women and 2 men) had thyroid nodules that were pathologically confirmed. Precontrast nodule attenuation was significantly lower in malignant nodules when compared with benign nodules (36 vs 61 HU, P = 0.05). Arterial phase and delayed phase nodule attenuations were not significantly different in malignant and benign nodules (128 vs 144 HU, P = 0.7; 74 vs 98 HU, P = 0.3).
CONCLUSIONS: Our initial experience with a small group of patients was unable to support the use of 4DCT for characterizing thyroid nodules; however, precontrast nodule attenuation was significantly lower in malignant nodules when compared with benign nodules.

PMID: 27560025 [PubMed - indexed for MEDLINE]

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