Role of uric acid therapy in prevention of early ischemic stroke progression

KC Rakshith, Saumya H Mittal, ZK Misri, Shivanand Pai

Astrocyte 2016 3(3):137-138

Objective: To study the role of uric acid (UA) in the outcome of thrombolysis after stroke. Materials and Methods: Our observational study was conducted over 5 years at the KMC Hospital, Mangalore from July 2011 to July 2016. All patients above the age of 18 years presenting to the hospital within 4.5 hours of stroke onset were included into the study. The patients' stroke severity was calculated by National Institute of Health Stroke Scale (NIHSS) score, whereas the outcome was measured by modified Rankin Scale (mRS) score. The patients were divided into good outcome, poor outcome, and expired groups of patients depending on the mRS score (<3, ≥3 but <6, and 6, respectively). UA in the blood was measured and recorded in all the included patients. At the end of the study, significance was calculated by standard statistical methods. Results: A total of 71.9% patients were found to have a good outcome, 24.2% patients had poor outcome, and the rest were in the expired group of patients. Among the good outcome patients, UA was found to be 4.6 ± 1.4 mg/dL, in the poor outcome group UA was 3.7 ± 1.1 mg/dL, and in expired group UA was 3.2 ± 0.6 mg/dL (P = 0.002). Conclusion: Our results suggest that UA has neuroprotective actions and can predict a good outcome among patients undergoing thrombolysis.

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