Methylphenidate effects on P300 responses from children and adolescents.

The attention deficit hyperactivity disorder (ADHD) is characterized by a lack of attention, by hyperactivity and impulsivity, by flawed academic performance, by problematic family and social relationships and by a need for psychosocial adjustment (1). Neuropsychological studies have suggested an association between ADHD and neural alterations in the prefrontal cortex and its projections in various subcortical structures (2, 3). Methylphenidate (MPH) is the most commonly prescribed central nervous system stimulant used to treat ADHD.

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