Systematic development of small molecules to inhibit specific microscopic steps of A{beta}42 aggregation in Alzheimer’s disease [Neuroscience]

The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in Alzheimer’s disease (AD). The use of chemical kinetics has recently enabled highly accurate quantifications of the effects of small molecules on specific microscopic steps in Aβ42 aggregation. Here, we exploit this approach to develop...

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