Τετάρτη 18 Ιανουαρίου 2017

Rotating night shift work, sleep, and colorectal adenoma in women.

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Rotating night shift work, sleep, and colorectal adenoma in women.

Int J Colorectal Dis. 2017 Jan 17;:

Authors: Devore EE, Massa J, Papantoniou K, Schernhammer ES, Wu K, Zhang X, Willett WC, Fuchs CS, Chan AT, Ogino S, Giovannucci E, Wei EK

Abstract
PURPOSE: This study aims to investigate the associations of rotating night shift work history and sleep duration with risk of colorectal adenoma.
METHODS: We evaluated 56,275 cancer-free participants of the Nurses' Health Study II, who had their first colonoscopy or sigmoidoscopy between 1991 and 2011; rotating night shift work and sleep duration were reported by mailed questionnaire. Multivariable-adjusted logistic regression was used to estimate relative risks (RR) of colorectal adenoma, with 95% confidence intervals (CI), across categories of rotating night shift work history (none, 1-4, 5-9, and ≥10 years) and sleep duration (≤5, 6, 7, 8, and ≥9 h/day).
RESULTS: We found no association between duration of rotating night shift work and occurrence of colorectal adenoma (p-trend across shift work categories = 0.5). Women with the longest durations of rotating night shift work (≥10 years) had a similar risk of adenoma compared to women without a history of rotating night shift work (multivariable-adjusted RR = 0.96, 95% CI = 0.83-1.11). Similarly, there were no associations of shorter or longer sleep durations with adenoma risk (p-trend = 0.2 across sleep durations of ≤5 through 7 h/day and p-trend = 0.5 across sleep durations of 7 through ≥9 h/day). Results were similar when we examined associations according to adenoma location and subtype.
CONCLUSIONS: Our results do not support an association between rotating night shift work or sleep duration and risk of colorectal adenoma in women.

PMID: 28097381 [PubMed - as supplied by publisher]



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