Lymphocyte function following radium-223 therapy in patients with metastasized, castration-resistant prostate cancer

Abstract

Purpose

Therapy with the alpha-emitter radium-223 chloride (²²³Ra) is an innovative therapeutic option in patients with metastasized, castration-resistant prostate cancer. However, radiotherapy can lead to hematopoietic toxicity. The aim of this study was to determine if ²²³Ra therapy induces an impairment of cellular antimicrobial immune responses.

Methods

In 11 patients receiving ²²³Ra treatment, lymphocyte proliferation and the production of pro- and anti-inflammatory cytokines (interferon-γ and interleukin-10) were determined, using lymphocyte transformation testing and ELISpot, respectively. Lymphocyte function after stimulation with mitogens and microbial antigens was assessed prior to therapy and at day 1, 7 and 28 after therapy.

Results

Lymphocyte proliferation and the production of interferon-γ and interleukin-10 towards mitogens and antigens remained unchanged after therapy. Consistent with these in vitro data, we did not observe infectious complications after treatment.

Conclusions

The results argue against an impairment of lymphocyte function after ²²³Ra therapy. Thus, immune responses against pathogens should remain unaffected.

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