Regulation of metastasis continues to remain enigmatic despite our improved understanding of cancer. Identification of microRNAs associated with metastasis in the recent past has provided a new hope. Here, we show how microRNA-101 (miR-101) regulates two independent processes of cellular metastasis by targeting pro-metastatic upstream regulatory transcription factors, ZEB1 and ZEB2, and downstream effector-actin modulators, RHOA and RAC1, providing a single target for therapeutic intervention. Further, we depict how down-regulation of miR-101 by extracellular signal-regulated kinase-2 (ERK2) is vital for MAP kinase pathway induced cellular migration and mesenchymal transition.
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Background Although pneumonia is a leading cause of death in New York City (NYC), limited data exist about the settings in which pneumonia ...
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The Trojan War was over. The clever Greek Odysseus had tricked the enemy into bringing a colossal wooden horse within the walls of Troy. The...
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Vol.30 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nItCSB via IFTTT
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New semi-pilot-scale reactor to study the photocatalytic inactivation of phages contained in aerosolAbstract The aims of this work were to design and build a photocatalytic reactor (UV-A/TiO 2 ) to study the inactivation of phages containe...
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A practice quiz on solving one step equations. Multiplication, Division, Addition, and Subtraction. from #AlexandrosSfakianakis via Alexan...
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Abstract The roles of phonological short-term memory (pSTM) and speech perception in spoken sentence comprehension were examined in an exp...
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List of the new elected members to the European Academy of Sciences from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader ...
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