The development of resistance to tamoxifen in patients with breast cancer: our experience

2016-10-21T00-09-15Z
Source: International Journal of Research in Medical Sciences
Sinisa Maksimovic, Biljana Marjanovic, Branislava Jakovljevic, Zdenka Gojkovic, Dejan Opric, Dusan Mileusnic.
Background: The study used data from medical and counselling of patients who were diagnosed with hormone-dependent breast cancer. Aim: The objective of the paper is to identify within a group of patients diagnosed with hormone sensitive breast cancer and those who have received adjuvant tamoxifen, and then to isolate the patients with whom the therapeutic effect of tamoxifen stopped (resistance to tamoxifen). Methods: The study analyzed 153 patients in the period from 2005 to 2011, at the Public Health Institution Hospital, Sveti Vračevi" in Bijeljina. Resistance to tamoxifen was developed by 60 patients (39.2%) and 93 patients (60.8%) did not develop resistance to it. Results: More common emergence of resistance is in the premenopausal group of patients (p


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