2016-10-21T00-09-15Z
Source: International Journal of Research in Medical Sciences
Shaimaa Abdelmalik Pessar.
Background: Sepsis is an important cause of neonatal morbidity and mortality. In Egypt, A multi-center study reported that 45.9% of the neonates admitted to neonatal intensive care units (NICUs) were due to suspected neonatal sepsis. Proper management is not guaranteed due to nonspecific symptoms and signs especially at the onset of disease, delay of culture results and high rate of false negative results. Attempts have been made to use hematologic parameters, acute phase reactants and cytokine profiles for early and accurate diagnosis of neonatal sepsis; however, none was adequately sensitive or specific. Polymorphonuclear elastase (PMN-E) is a serine protease secreted during inflammatory diseases. The aim of the current study was to explore the reliability of PMN-E level for the diagnosis of neonatal sepsis and assess response to treatment in comparison to hematological parameters and C - reactive protein (CRP). Methods: The study comprised 30 neonates with proven sepsis, 30 neonates as control group. Both groups were subjected to calculation of hematologic sepsis score (HSS), CRP measurement, blood culture and serum PMN-E levels, the latter was measured both at diagnosis and 6 days after treatment in sepsis group. Results: Serum PMN-E levels were significantly higher in sepsis group (118.4±21.8) than in control group (57.9±27.9) and the best cut-off value was at 85 ng/ml with 97% sensitivity and 81% specificity, PMN-E levels also decreased significantly with response to treatment. Conclusions: Raised PMN-E level was found to be a diagnostic and prognostic marker in neonates with sepsis comparable with CRP and HSS.
http://ift.tt/2eruSXn
Παρασκευή 21 Οκτωβρίου 2016
Evaluation of polymorphonuclear leukocyte elastase levels in neonatal sepsis
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Treatment effectiveness holds considerable importance in the association between service quality and satisfaction in medical service studies...
-
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2jCvX3K via IFTTT
-
FS Teni, AS Surur, A Hailemariam, A Aye, G Mitiku, AE Gurmu, B Tessema Annals of Medical and Health Sciences Research 2015 5(6):454-460 ...
-
Abstract Purpose Gastric cancer (GC) is one of the fatal malignancies worldwide with high occurrences but poor outcomes. bFGF has been s...
-
We provide excellent essay writing service 24/7. Enjoy proficient essay writing and custom writing services provided by professional academi...
-
Daily Mail Sarah was diagnosed with the cancer that killed Steve Jobs Daily Mail The symptoms Sarah Smith experienced on and off for...
-
Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through ectasia, opacity, and irregular astigmatism. It ...
-
The Role of the Mammalian Prion Protein in the Control of Sleep. Pathogens. 2017 Nov 17;6(4): Authors: Roguski A, Gill AC Abstract ...
-
To date, the impact of conductive hearing loss on the auditory pathway at brainstem level has only been investigated in animal studies, whic...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου