Immunoglobulin profile in pulmonary tuberculosis in endemically prevalent Kashmiri population, Kashmir, India

2016-10-21T02-09-39Z
Source: International Journal of Research in Medical Sciences
Mohd Mubarik Naqash, Arif Nabi Bhat.
Background: Kashmir valley is endemically prevalent destination for tuberculosis. The role of T cell mediated immunity is very well known in the pathogenesis of tuberculosis. However, the B cell immune response has been studied less often. Thus, it was very interesting to estimate the levels of serum immunoglobulins in pulmonary tuberculosis. Methods: Serum levels of the immunoglobulins IgG, IgA and IgM were evaluated in 100 adult patients of untreated sputum positive cases of pulmonary tuberculosis in the age group of 20-65 years (36.42±8.95) and 50 controls of the same age group (34.26±9.46). The Immunoglobulins were estimated using single radial immunodiffusion method of Mancini et al. Results: The mean IgG and IgA levels were observed to be significantly increased in the patient group when compared with the controls (P


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