The application of platelet rich plasma in the treatment of deep dermal burns: A randomized, double blind, intra-patient controlled study

Abstract

Platelet rich plasma (PRP) is a fraction of blood with a platelet concentration above baseline. When platelets get activated, growth factors involved in wound healing are released. The application of PRP has shown good results in wound care, however up to date no substantial research has been performed on the effect of PRP in burn treatment. This randomized double blind intra-patient controlled study investigates the effect of autologous PRP on wound healing in burns that require surgery with a meshed split skin graft (SSG). 52 patients with various areas of deep dermal to full thickness burns, receiving surgery with a SSG were included after informed consent. Comparable study areas A and B (intra patient) were appointed, randomized and either treated with a SSG and PRP or with a SSG alone. At day 5 to 7 post- operative, the epithelialization and graft take rate were assessed. 3, 6 and 12 months post-operative, follow-up measurements were performed in the form of POSAS-questionnaires, DermoSpectroMeter and Cutometer measurements. There was no statistically significant difference between the mean take rate nor the mean epithelialization rate at day 5-7 between the PRP-treated and control areas. However, PRP-treated wound areas showed more often better or equal epithelialization and take rates at day 5-7 than the standard treated areas. Minor effects were also seen in the re-operated and early operated subgroups. At 3, 6 and 12 months post operative, POSAS scores from the patients and the observers, Dermaspectro- and Cutometer measurements did not depict a significant difference between the PRP and standard treated areas. Concluding, the addition of PRP in the treatment of burn wounds did not result in improved graft take and epithelialization, nor could we demonstrate better scar quality. There was, however, a considerable variation in our clinical population. This article is protected by copyright. All rights reserved.

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