Injectable bioactive glass in the restoration of oral bone defect

OBJECTIVE: To explore the application value of injectable bioactive glass in the restoration of the oral bone defect.

PATIENTS AND METHODS: This study included 58 consecutive patients with oral bone defect > 1 mm, these patients were randomly assigned to a control group (n=26, Hydroxyapatite bioceramics) and an observation group (n=32, Injectable bioactive glass). The purpose of this study was to assess the comparison of the healing of oral bone defect.

RESULTS: X-ray examination was performed at 6-month and 12-month following treatment. The bone healing in the observation group was significantly better than the control group (p <0.05), the incidences of local rejection reactions were not significantly different (p >0.05). Cone-beam Computed Tomography (CBCT) was performed at 6-month and 12-month following treatment. The mean bone thickness in the observation group was significantly lower than the control group, p <0.05. Both the levels of bone morphogenetic protein 2 (BMP-2) and transforming growth factor β (TGF-β) in the observation group were significantly higher than the control group, p <0.05.

CONCLUSIONS: The effect of injectable bioactive glass in the restoration of the oral bone defect was better than hydroxyapatite bioceramics. Thus, injectable bioactive glass has great application value.

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