Human Adaptive Natural Killer Cells: Beyond NKG2C

Publication date: Available online 11 May 2016
Source:Trends in Immunology
Author(s): Julia A. Wagner, Todd A. Fehniger
Paradigm-shifting studies have identified NKG2C⁺ adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently in Cell Reports, Liu et al. demonstrate that NKG2C^−/− HCMV⁺ individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/CD16.



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