18F‐FDG PET/MRI vs MRI in patients with recurrent adenoid cystic carcinoma

Abstract

Objectives

To evaluate and compare the diagnostic potential of ¹⁸F‐fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (¹⁸FDG‐PET/MRI) and MRI for recurrence diagnostics after primary therapy in patients with adenoid cystic carcinoma (ACC).

Methods

A total of 32 dedicated head and neck ¹⁸F‐FDG PET/MRI datasets were included in this analysis. MRI and ¹⁸F‐FDG PET/MRI datasets were analyzed in separate sessions by two readers for tumor recurrence or metastases.

Results

Lesion‐based sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were 96%, 84%, 90%, 93%, and 91% for ¹⁸F‐FDG PET/MRI and 77%, 94%, 95%, 73%, and 84% for MRI, resulting in a significantly higher diagnostic accuracy of ¹⁸F‐FDG PET/MRI compared to MRI (P < .005).

Conclusion

¹⁸F‐FDG PET/MRI is superior to MRI in detecting local recurrence and metastases in patients with ACC of the head and neck. Especially concerning its negative predictive value, ¹⁸F‐FDG PET/MRI outperforms MRI.

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