The effect of ovariectomy and two antiresorptive therapeutic agents on bone response in rats: a three-dimensional imaging analysis

To evaluate bone mineral density (BMD) and microarchitecture in femurs and maxillary bones of ovariectomized (OVX) rats treated or not treated with alendronate (ALD) or odanacatib (ODN).Study Design: Twenty rats were divided into groups: SHAM, OVX, OVX/ALD and OVX/ODN. After 12 weeks, the femurs and maxillae were removed and subjected to three-dimensional analysis by microcomputed tomography. Results were analyzed with one-way ANOVA and Tukey's test (α=0.05).

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