Surfactant protein D (SP-D) is a known regulator of pulmonary immunity, and administration of a recombinant fragment of the protein (rfhSP-D) attenuates allergic airway inflammation in experimental murine models. Qassim et al (Am J Respir Crit Care Med 2017;196:1526-34; doi: http://ift.tt/2nFsJgh) examined the effect of rfhSP-D on grass pollen allergen–induced basophil and adaptive immune cell responses using primary blood cells and sera obtained from human subjects with known grass pollen allergy.
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