Perilesional edema in brain cancer: Independent prognosticator or epiphenomenon of biomolecular signature?

We read with great interest the paper by Liang entitled "The extent of edema and tumor synchronous invasion into the subventricular zone and corpus callosum classify outcomes and radiotherapy strategies of glioblastomas" [1] that has addressed the importance of perilesional edema (PE) and of the invasion into synchronous subventricular zone and corpus callosum (sSVZCC), as a strong prognostic factor in an homogeneous cohort of glioblastoma patients.

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