The cover of this issue relates to one of five articles on tau. Using 18F-AV-1451 PET scanning, Merle Hoenig and colleagues report that tau pathology expands along independent pathways that correspond to functional networks known to be impaired in Alzheimer’s disease, including the default mode network and the frontal control network. Thomas Cope and co-workers also show that highly connected networks are susceptible to tau pathology in Alzheimer’s disease. Such a relationship was, however, not seen in progressive supranuclear palsy, where the burden appears to correlate instead with increased metabolic demand or lack of trophic support. The pathogenic role of tau remains at the centre of much research published in Brain. Marie d’Orange and colleagues compare the effect of viral expression of either wild-type tau or a chimeric protein designed to aggregate tau in rat brain, and conclude that potentiating tangle formation reduces acute toxicity of soluble tau species. Shelley Forrest and co-workers show that distinct mutations of the MAPT gene that encodes tau result in pathologies that strongly resemble sporatic sporadic frontotemporal tauopathies. Finally, Chad Tagge, Andrew Fisher, Olga Minaeva and colleagues report that impact head injury can result in early phosphorylated tau pathology in experimental models, and identify similar changes in a small number of young athletes who died suddenly within 4 months of a closed-head injury.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2Gu4uJO
via IFTTT
Τρίτη 30 Ιανουαρίου 2018
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Background Hyperthyroidism is associated with increased thrombotic risk. As contact system activation through formation of neutrophil extrac...
-
UM-Chor1: establishment and characterization of the first validated clival chordoma cell line. J Neurosurg. 2017 Apr 21;:1-9 Authors:...
-
Publication date: Available online 10 May 2017 Source: Journal of Dairy Science Author(s): R.E. Vibart, M. Tavendale, D. Otter, B.H. Schw...
-
Competency-based psychiatric education for Indian medical undergraduates Vijayalakshmi Pernenkil Archives of Mental Health 2019 20(1):1-2 Be...
-
Related Articles Developmental control of macrophage function. Curr Opin Immunol. 2017 Dec 13;50:64-74 Authors: Bonnardel J, Guillia...
-
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2tcPIjn via IFTTT
-
Abstract: Epidermolytic ichthyosis (EI) is a rare disorder of cornification caused by mutations in KRT1 and KRT10, encoding two suprabasal e...
-
Bloomberg Celgene Settles Whistle-Blower Fraud Suit for $280 Million Bloomberg Even after the FDA approved Thalomid for multiple myelo...
-
Related Articles Chinese version of the Constant-Murley questionnaire for shoulder pain and disability: a reliability and validation ...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου