The past, present, and future of selective progesterone receptor modulators in the management of uterine fibroids.

The past, present, and future of selective progesterone receptor modulators in the management of uterine fibroids.

Am J Obstet Gynecol. 2017 Dec 21;:

Authors: Singh SS, Belland L, Leyland N, von Riedemann S, Murji A

Abstract
Uterine fibroids (UF) are common in women of reproductive age and can have a significant impact on quality of life and fertility. Although a number of international OB/GYN societies have issued evidence-based clinical practice guidelines for the management of symptomatic UF, many of these guidelines do not yet reflect the most recent clinical evidence and approved indication for one of the key medical management options: the selective progesterone receptor modulator (SPRM) class. This paper aims to share the clinical experience gained with SPRMs in Europe and Canada by reviewing the historical development of SPRMs, current best practices for SPRM use based on available data, and potential future uses for SPRMs in UF and other gynecologic conditions.

PMID: 29274830 [PubMed - as supplied by publisher]

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