IJERPH, Vol. 15, Pages 27: Association between Exposure to Ambient Air Particulates and Metabolic Syndrome Components in a Saudi Arabian Population

IJERPH, Vol. 15, Pages 27: Association between Exposure to Ambient Air Particulates and Metabolic Syndrome Components in a Saudi Arabian Population

International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15010027

Authors: Magdy Shamy Mansour Alghamdi Mamdouh Khoder Abdullah Mohorjy Alser Alkhatim Abdulrahman Alkhalaf Jason Brocato Lung Chen George Thurston Chris Lim Max Costa

Recent epidemiological evidence suggests that exposure to particulates may be a factor in the etiology of metabolic syndrome (MetS). In this novel study, we investigated the relationship between particulate levels and prevalence of MetS component abnormalities (hypertension, hyperglycemia, obesity) in a recruited cohort (N = 2025) in Jeddah, Saudi Arabia. We observed significant associations between a 10 μg/m3 increase in PM2.5 and increased risks for MetS (Risk Ratio (RR): 1.12; 95% Confidence Interval (CI): 1.06–1.19), hyperglycemia (RR: 1.08; 95% CI: 1.03–1.14), and hypertension (RR: 1.09; 95% CI: 1.04–1.14). PM2.5 from soil/road dust was found to be associated with hyperglycemia (RR: 1.12; 95% CI: 1.06–1.19) and hypertension (RR: 1.11; 95% CI: 1.05–1.18), while PM2.5 from traffic was associated with hyperglycemia (RR: 1.33; 95% CI: 1.05–1.71). We did not observe any health associations with source-specific mass exposures. Our findings suggest that exposure to specific elemental components of PM2.5, especially Ni, may contribute to the development of cardiometabolic disorders.

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