BTB/POZ domain-containing protein 7 is inversely associated with fibronectin expression in salivary adenoid cystic carcinoma

Publication date: Available online 28 December 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Yunxia Liu, Jiwu Song, Jun Zhang, Liu Yang, Zongxia Liu, Xuxia Wang
ObjectiveThis study was aimed to investigate the relationship between BTB/POZ domain-containing protein 7 (BTBD7) and fibronectin (FN) expression in salivary adenoid cystic carcinoma (SACC) and the function of BTBD7 in proliferation, migration and invasion of SACC cells.MethodsThe BTBD7 and FN expression in SACC and non-tumor salivary tissues as well as SACC cells were characterized by immunohistochemistry and immunofluorescence. The effect of BTBD7 silencing on the proliferation, migration and invasion of SACC-LM cells were determined by wound healing and transwell invasion assays.ResultsThe percentages of SACC with positive BTBD7 expression were significantly higher than that of those with FN expression. BTBD7 silencing significantly increased the relative levels of FN expression and inhibited the proliferation, migration and invasion of SACC-LM cells.ConclusionsThe data indicated that BTBD7 was inversely associated with FN expression in SACC. BTBD7 may inhibit FN expression, but promote proliferation, migration and invasion of SACC-LM cells. Hence, BTBD7 may be associated with metastasis and a new therapeutic target for intervention of SACC.



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