Neutrophil to lymphocyte ratio predict mortality and major adverse cardiac events in acute coronary syndrome: A systematic review and meta-analysis

Publication date: Available online 11 November 2017
Source:Clinical Biochemistry
Author(s): Chao-Hui Dong, Zhang-Min Wang, Si-Yu Chen
ObjectivesNeutrophil to lymphocyte ratio (NLR) might be associated with the mortality or major adverse cardiac events (MACEs) in acute coronary syndrome (ACS) patients. We performed a meta-analysis to evaluate the correlation between NLR and mortality/MACEs in ACS.MethodsWe assessed clinical trials through Pubmed, EMBASE, the Cochrane Library and Web of science in investigating the association between NLR and mortality/MACEs in ACS patients up to August 15, 2017. The primary outcome was mortality or recurrent MACEs.ResultsIn total, 8 studies of 9406 patients were included in the systematic and meta-analysis. Our analysis indicated that elevated pretreatment NLR was a poor prognostic marker for patients with recent ACS in predicting medium to long-term mortality/MACEs (OR 1.26, 95%CI 1.13–1.41). And the analysis indicated that higher pretreatment NLR value was associated with higher in-hospital mortality in ACS patients (OR 6.39, 95%CI 1.49–27.38, p<0.001). The NLR value of 5.0 maybe a cut-off value for ACS risk.ConclusionsIn patients with a recent ACS, an elevated pretreatment NLR value is effective in predicting the risk of mortality/MACEs.



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