Automated Brain Tissue and Myelin Volumetry Based on Quantitative MR Imaging with Various In-plane Resolutions

Publication date: Available online 11 November 2017
Source:Journal of Neuroradiology
Author(s): Christina Andica, Akifumi Hagiwara, Masaaki Hori, Misaki Nakazawa, Masami Goto, Saori Koshino, Koji Kamagata, Kanako K Kumamaru, Shigeki Aoki
Background and purposeSegmented brain tissue volume and myelin volume can now be automatically calculated using the SyMRI, which is based on quantification of R1 and R2 relaxation rates and proton density. The aim of this study was to determine the validity of SyMRI brain tissue and myelin volumetry using various in-plane resolutions.MethodsWe scanned 10 healthy subjects on a 1.5 T MR scanner with in-plane resolutions of 0.8, 2.0, and 3.0mm. Two scans were performed for each resolution. The acquisition time was 7-min and 24-sec for 0.8mm, 3-min and 9-sec for 2.0mm, and 1-min and 56-sec for 3.0mm resolutions. The volumes of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), non-WM/GM/CSF (NoN), brain parenchymal volume (BPV), intracranial volume (ICV) and myelin were compared between in-plane resolutions. Repeatability for each resolution was then analyzed.ResultsNo significant differences in volumes measured were found between the different in-plane resolutions, except for NoN between 0.8mm and 2.0mm and between 2.0mm and 3.0mm. The repeatability error value for the WM, GM, CSF, NoN, BPV, and myelin volumes relative to ICV was 0.97%, 1.01%, 0.65%, 0.86%, 1.06%, and 0.25% in 0.8mm; 1.22%, 1.36%, 0.73%, 0.37%, 1.18%, and 0.35% in 2.0mm; and 1.18%, 1.02%, 0.96%, 0.45%, 1.36%, and 0.28% in 3.0mm resolutions.ConclusionSyMRI brain tissue and myelin volumetry with low in-plane resolution and short acquisition times is robust and has a good repeatability, so could be useful for follow-up studies.



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