IJMS, Vol. 18, Pages 2454: Cytotoxicity of Poly(Alkyl Cyanoacrylate) Nanoparticles

IJMS, Vol. 18, Pages 2454: Cytotoxicity of Poly(Alkyl Cyanoacrylate) Nanoparticles

International Journal of Molecular Sciences doi: 10.3390/ijms18112454

Authors: Einar Sulheim Tore-Geir Iversen Vu To Nakstad Geir Klinkenberg Håvard Sletta Ruth Schmid Anne Hatletveit Ane Wågbø Anders Sundan Tore Skotland Kirsten Sandvig Ýrr Mørch

Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated in several cell lines with different methods and on multiple nanoparticle batches. Here we report the toxicity of poly(alkyl cyanoacrylate) nanoparticles in 12 different cell lines after synthesizing and analyzing 19 different nanoparticle batches and report that large variations were obtained when using different cell lines or various toxicity assays. Surprisingly, we found that nanoparticles with intermediate degradation rates were less toxic than particles that were degraded faster or more slowly in a cell-free system. The toxicity did not vary significantly with either the three different combinations of polyethylene glycol surfactants or with particle size (range 100–200 nm). No acute pro- or anti-inflammatory activity on cells in whole blood was observed.

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