Prognostic value of alkaline phosphatase in patients with acute coronary syndromes

Publication date: Available online 1 June 2017
Source:Clinical Biochemistry
Author(s): Gjin Ndrepepa, Stefan Holdenrieder, Erion Xhepa, Salvatore Cassese, Massimiliano Fusaro, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
ObjectivesThe objective of the study was to investigate the association between alkaline phosphatase (AP) activity and prognosis of patients with acute coronary syndrome (ACS).Design and methodsThe study included 2134 patients with ACS undergoing percutaneous coronary intervention. All included patients had baseline AP measurements available. The receiver operating characteristic curve analysis showed that the best cut-off of AP for mortality prediction was 98.0U/L. Using this cut-off, patients were divided into two groups: a group with AP>98.0U/L (n=493) and a group with AP≤98.0U/L (n=1641). The primary endpoint was 3-year mortality.ResultsOverall, there were 229 deaths over the follow-up: 90 deaths among patients with an AP >98.0U/L and 139 deaths among patients with an AP≤98.0U/L (Kaplan-Meier estimates of 3-year total mortality), 19.5% and 9.3%, respectively; (adjusted hazard ratio [HR]=1.37, 95% confidence interval [CI] 1.10–1.70, P=0.004 for each unit higher log AP). Cardiac deaths occurred in 157 patients: 66 deaths among patients with an AP>98.0U/L and 91 deaths among patients with an AP≤98.0U/L (Kaplan-Meier estimates of 3-year total mortality), 14.3% and 6.0%, respectively; (adjusted HR=1.32 [1.02–1.70], P=0.033, for each unit higher log AP). The C-statistic of the multivariable model with baseline variables was 0.836 [0.807–0.866] and increased to 0.842 [0.814–0.874] after inclusion of AP (P=0.045).ConclusionsIn patients presenting with an ACS and treated with percutaneous coronary intervention, elevated AP activity is associated with increased risk of subsequent mortality.



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