Response to “Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer,” Cancer Lett. 2017 Mar 1; 388(2017): 208-219

We much appreciated for the comment on our manuscript[1]. However, there are some misunderstanding in this comment. Firstly, the authors concluded that circPVT1 played a cancer suppressor role in vivo (from the clinical correlation), while was proved to act an oncogene in vitro (from the functional assays). However, the clinical correlation (biomarker) may have no functional implication. We were also very curious about the contradiction between clinical implication and cellular function of circPVT1 in GC.

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