Polymorphisms of chemokine receptor genes and clearance of hepatitis C virus infection in Chinese population

Publication date: 15 August 2017
Source:Gene, Volume 624
Author(s): Mingzhu Chen, Yinan Yao, Ming Yue, Feng Zang, Mei Liu, Jie Wang, Hongbo Chen, Yun Zhang, Jun Li, Peng Huang, Rongbin Yu
BackgroundChemokine genes play an essential role in both spontaneous clearance in acute infection and therapy of HCV. We investigated whether several CXC family-related genes associated with HCV spontaneous clearance and response to treatment.MethodsThe current study genotyped four SNPs, respectively are CXCR6 rs2234358, CXCL12 rs1801157, CXCL9 rs10336, rs3733236 to assess their associations with HCV spontaneous clearance and response to treatment in a two stage study (668 chronic and 400 resolvers in discovery group, meanwhile 333 chronic and 199 resolver in replication group), and a treatment cohort of HCV with 282 patients.ResultsWe found that the CXCR6 rs2234358 was associated with HCV spontaneous clearance in Chinese Han population (dominant model: adjusted OR=1.62, 95%CI: 1.30–2.01; additive model: adjusted OR=1.43, 95%CI: 1.20–1.70). Patients carrying GT/TT genotypes had increased sustained virological response compared with patients carrying the GG genotype (dominant model: adjusted OR=2.23, 95%CI: 1.26–3.95).ConclusionThese results suggest that CXCR6 rs2234358 is associated with spontaneous clearance of HCV and response to IFN-α/RBV therapy, which may be identified as a predictive marker in Chinese Han population of HCV.



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