Publication date: Available online 29 May 2017
Source:Clinical Biochemistry
Author(s): David Ivars, Maria Teresa Orero, Karla Javier, Laura Díaz-Vico, José Luis García-Giménez, Salvador Mena, Carmen Tormos, Mercedes Egea, Pedro Luis Pérez, Beatriz Arrizabalaga, María Ángeles Ruiz, Nuria Yagüe, Mar Tormo, Reyes Sancho-Tello, Angela Gomes, Carmen Algueró, José Enrique O'Connor, Guillermo T. Sáez, Félix Carbonell, Rosa Collado
ObjectiveTo assess the generation of reactive oxygen species (ROS) and the involvement of the main antioxidant pathways in low/intermediate-1-risk myelodysplastic syndromes (MDS) with iron overload (IOL).MethodsWe examined the levels of superoxide anion (O2−), hydrogen peroxide (H2O2), antioxidants (glutathione, GSH; superoxide dismutase, SOD; catalase, CAT; and glutathione peroxidase, GPx), mitochondrial membrane potential (ΔΨm), and by-products of oxidative damage (8-isoprostanes and 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-dG) in 42 MDS patients (28 without IOL at diagnosis, and 14 who developed IOL) and 20 healthy subjects.ResultsPatients with IOL showed higher O2− levels (39.4 MFI) than normal controls (22.7 MFI, p=0.0356) and patients at diagnosis (19.4 MFI, p=0.0049). Antioxidant systems, except SOD activity, exhibited significant changes in IOL patients with respect to controls (CAT: 7.1 vs 2.7nmol/ml/min, p=0.0023; GPx: 50.9 vs 76.4nmol/ml/min, p=0.0291; GSH: 50.2 vs 24.1 MFI, p=0.0060). Furthermore, mitochondrial dysfunction was only detected in IOL cases compared to controls (ΔΨm: 3.6 vs 6.4 MFI, p=0.0225). Finally, increased levels of 8-oxo-dG were detected in both groups of patients.ConclusionOxidative stress is an important but non-static phenomenon in MDS disease, whose status is influenced by, among other factors, the presence of injurious iron.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2rOzMqe
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
A study using a new computer-aided detection (CAD) algorithm found breast cancers... Read more on AuntMinnieEurope.com Related Reading: ...
-
Ahead of print: Prävalenz und Risikofaktoren der felinen Hyperthyreose in einer Klinikpopulation ...Ziel: Die feline Hyperthyreose ist eine häufige Endokrinopathie bei älteren Katzen. In früheren Studien wurden unausgewogene Ernährung, Schi...
-
Dicyclohexyl phthalate (DCHP) is one of the phthalate plasticizers. The objective of the present study was to investigate the effects of DCH...
-
Health Promotion in the Community: Impact of Faith-Based Lay Health Educators in Urban NeighborhoodsAbstract Promoting wellness and providing reliable health information in the community present serious challenges. Lay health educators, al...
-
Abstract To characterize the anatomical connectivity of the prelemniscal radiations (Raprl), a white matter region within the posterior sub...
-
Predictors of postoperative pneumonia in patients undergoing oral cancer resections and its management p. 69 Ridhi Sood, Jerry Paul, Sunil...
-
from Imaging via alkiviadis.1961 on Inoreader http://ift.tt/2Gb1m5b
-
This work presents the nonlinear dynamical analysis of a multilayer piezoelectric macrofiber composite (MFC) laminated shell. The effects of...
-
The upper reaches of the Heihe River have been regarded as a hotspot for phytoecology, climate change, water resources and hydrology studies...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου