Expression of PD-L1 in tumor cells and infiltrating immune cells was retrospectively analyzed in a cohort of surgically-treated non-small cell lung cancer patients. There was significant discordance of PD-L1 expression between different tumor areas, especially in the immune cell compartment. Heterogeneous PD-L1 expression represents a challenge for adequate biomarker-based selection of patients for PD-1/PD-L1-directed therapies.
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Background. Reconstruction of surgical defects following cranial base surgery is challenging. Others have demonstrated that leukocyte-platel...
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During lytic infection, herpes simplex virus (HSV) DNA is replicated by a mechanism involving DNA recombination. For instance, replication o...
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Outcomes of multimodal management for sinonasal squamous cell carcinoma. J Craniomaxillofac Surg. 2017 May 12;: Authors: Paré A, Blan...
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Abstract Purpose Low back pain is a significant problem for school-aged athletes. Although some risk factors relating to sports activiti...
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Thyroid cancer is the most common malignant tumor of the endocrine system and the incidence has been increasing in recent years. In a great ...
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