Colorectal cancer subtypes: Translation to routine clinical pathology

Colorectal cancer (CRC) is the second most common cause of cancer death in Europe [1]. Although outcomes have improved over the past decades, predominantly as a result of improvements in surgical technique and adjuvant/neo-adjuvant therapies, survival remains poor, with an overall 5-year survival of approximately 50% [2]. Therefore, there remains a need to identify characteristics pertaining to both the tumour and microenvironment which may not only guide prognosis, but also provide novel targets for adjuvant therapies.

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