Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth

by Alexandra B. Ysasi, Willi L. Wagner, Cristian D. Valenzuela, Arne Kienzle, Andrew B. Servais, Robert D. Bennett, Akira Tsuda, Maximilian Ackermann, Steven J. Mentzer

In many mammals, including rodents and humans, removal of one lung results in the compensatory growth of the remaining lung; however, the mechanism of compensatory lung growth is unknown. Here, we investigated the changes in morphology and phenotype of pleural cells after pneumonectomy. Between days 1 and 3 after pneumonectomy, cells expressing α-smooth muscle actin (SMA), a cytoplasmic marker of myofibroblasts, were significantly increased in the pleura compared to surgical controls (p + cells relative to pneumonectomy-plus-plombage controls (p

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