Comment on “Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer,” Cancer Lett. 2017 Mar 1; 388(2017): 208-219

With great interest, we read a recent article in Cancer Letters by Chen et al [1], which reported that a novel circular RNA, circPVT1, was screened from ribo-minus RNA sequencing data of gastric cancer (GC) tissues. Afterwards, circPVT1 was analysed up-regulated in both GC tissues and cells. In addition, this circular RNA was proved to inhibit the proliferation of gastric cancer (GC) cells by silencing, which was very significant. Surprisingly, circPVT1 was proved to be negatively associated with T4 stage and nervous invasion.

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