Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues

Publication date: 23 May 2017
Source:Cell Reports, Volume 19, Issue 8
Author(s): Davalyn Powell, Sebastien Tauzin, Laurel E. Hind, Qing Deng, David J. Beebe, Anna Huttenlocher
Motile cells navigate through complex tissue environments that include both attractive and repulsive cues. In response to tissue wounding, neutrophils, primary cells of the innate immune response, exhibit bidirectional migration that is orchestrated by chemokines and their receptors. Although progress has been made in identifying signals that mediate the recruitment phase, the mechanisms that regulate neutrophil reverse migration remain largely unknown. Here, we visualize bidirectional neutrophil migration to sterile wounds in zebrafish larvae and identify specific roles for the chemokine receptors Cxcr1 and Cxcr2 in neutrophil recruitment to sterile injury and infection. Notably, we also identify Cxcl8a/Cxcr2 as a specific ligand-receptor pair that orchestrates neutrophil chemokinesis in interstitial tissues during neutrophil reverse migration and resolution of inflammation. Taken together, our findings identify distinct receptors that mediate bidirectional leukocyte motility during interstitial migration depending on the context and type of tissue damage in vivo.

Graphical abstract

Teaser

Powell et al. describe disparate roles for the chemokine receptors Cxcr1 and Cxcr2 in neutrophil recruitment to, and resolution from, tail-transection wounding in larval zebrafish. Their work suggests that Cxcl8-Cxcr2 signaling drives neutrophil reverse migration from the wound by promoting random migration after exposure to Cxcl8.


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2qaMJug
via IFTTT