The relationship between tumor location and outcome in patients with early-stage lung cancer

We read with interest the recent article by Shaverdian et al,1 based on a single institution cohort of 122 patients with stage I (T1-2AN0M0) lung cancer. They reported that on multivariable analysis tumors in the lower lobes were associated with worse relapse-free and overall survival (HR=2.8 and 2.3 respectively) after treatment with stereotactic body radiotherapy. One hypothesis is that because such tumors may be more mobile,2 they may be more prone to inaccuracies in radiotherapy targeting.

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