The ErbB family and androgen receptor signaling are targets of Celecoxib in prostate cancer

Inflammation plays a central role in prostate cancer (PCa) development through significant crosstalk between the COX2- ErbB family receptor network and androgen receptor (AR)-EGFR signaling pathways. The purpose of this work was to determine the ability of the COX-2 inhibitor Celecoxib to modulate the EGFR-AR signaling pathway in androgen-dependent PCa cells and to provide a rationale for its beneficial use in chemopreventive strategies. Functional studies of Celecoxib activity were performed on LNCaP prostate cancer cells.

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