The anticancer agent 3-bromopyruvate (3-BP) is viewed as a glycolytic inhibitor that preferentially kills glycolytic cancer cells through energy depletion. However, its cytotoxic activity is dependent on cellular drug import through transmembrane monocarboxylate transporter 1 (MCT-1), which restricts its anticancer potential to MCT-1-positive tumor cells. We created and characterized an MCT-1-independent analog of 3-BP, called NEO218. NEO218 was synthesized by covalently conjugating 3-BP to perillyl alcohol (POH), a natural monoterpene.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pfyMK9
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1tk1BEi via IFTTT
-
PSA! Has a TON of Scholarship Opportunities Right Now. SPOILER: college is crazy-expensive. Sorry. Did we spoil it? There are... from #Ale...
-
The National Booster Club Training Council, Providing Guidance, Education, Training and Support from #AlexandrosSfakianakis via Alexandros...
-
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p6KhjG via IFTTT
-
Purpose. To assess the long-term clinical outcomes of conventional laser in situ keratomileusis (LASIK) for moderate to high myopia. Methods...
-
Fun math practice! Improve your skills with free problems in 'Solve two-step equations' and thousands of other practice lessons. f...
-
How to Write a Master's Thesis. Students learning how to write a Master's Thesis will first learn that a central thesis question mus...
-
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nA3sSF via IFTTT
-
An in-depth look at what makes Rolex the industry leader and icon that they are, as we bring you inside the Rolex manufacturing facilities. ...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου