The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study

by Sigrid Børte, Bendik S. Winsvold, Synne Øien Stensland, Milada Cvancarova Småstuen, John-Anker Zwart

Background

There is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults.

Methods

The population-based Nord-Trøndelag Health Study (HUNT 3) contained a validated headache questionnaire, which differentiated between migraine and tension-type headache. These data were linked to information on weight and gestational age at birth from the Norwegian Medical Birth Registry. In total 4557 females and 2789 males, aged 19–41 years, were included in this registry-based study. Participants were categorized as appropriate for gestational age (AGA, 10^th-90^th percentile), small for gestational age (SGA, 3^rd-10^th percentile) or very small for gestational age (VSGA, rd percentile). Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for migraine and tension-type headache, with exposure being growth restriction at birth.

Results

The effect of growth restriction on migraine was modified by sex, with a significant association in males (p Conclusion

Growth restriction was associated with increased risk of migraine in adulthood among males, but not among females. This suggests that migraine might, in part, be influenced by early life events, and that males seem to be particularly vulnerable.

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