Alcohol-associated cancer and deregulation of Pol III genes

Publication date: 15 May 2017
Source:Gene, Volume 612
Author(s): Ganggang Shi, Shuping Zhong
Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism of alcohol-promoted cell transformation and tumor development. Alcohol induces JNK1 activation and increases cellular levels of c-Jun to upregulate Brf1 expression and Pol III gene transcription, leading to an enhancement of rates of cell transformation and tumor formation.



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