Aged patients with metastatic castration resistant prostate cancer: should we treat with chemotherapy?

As industrialized populations get older and life expectancy increases, the number and proportion of elderly patients with cancer is rising, and this trend is expected to continue in the western and industrialized world. More than half of new cancers occur in the elderly. Prostate cancer is a disease largely affecting older men. Median age at diagnosis is 67years, with 70.6% of prostate cancer deaths occurring in men older than75 [1]. Moreover, prostate cancer is the most frequently diagnosed cancer in men in both the USA [2] and Europe [3], and one of the three most common causes of cancer-related death.

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