Possible effect of landscape design on IgE recognition profiles of two generations revealed with micro-arrayed allergens

Abstract

Aim of this study was to investigate possible effects of landscape design on IgE-sensitization profile towards inhalant allergens in patients with respiratory allergy from Uzbekistan where green areas have been changed during the last 2 decades by a State program. Sera from two different generations of Uzbek (n=58) and, for control purposes, from two generations of Austrian (n=58) patients were analyzed for IgE reactivity to 112 different micro-arrayed allergen molecules by ImmunoCAP ISAC technology. Changes of molecular IgE sensitization profiles to pollen allergens in the young versus the middle-aged Uzbek population were associated with replanting whereas those in the Vienna populations reflected natural changes of plant growth. Our data indicate that anthropologic as well as natural changes of the biome may have effects on IgE sensitization profiles already from one to another generation.

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