Detection of genetic alterations mastering lung cancer biology provides suitable targets for personalized anti-cancer therapy. In non-small cell lung cancer (NSCLC), activating mutations of EGFR, HER2, BRAF, MET, as well as gene fusions involving ALK, ROS1, RET, the members of NTRK and FGFR families, govern the oncogenic potential of malignant cells. The detection and targeting of those genetic abnormalities have demonstrated major improvement in clinical outcomes. Altogether, genetic alterations suitable of targeted treatments are currently detected in 30-40% of advanced non-small cell lung cancers (mainly adenocarcinomas) in Western populations [1]; in Asian countries the prevalence is higher, due to the elevated percentage of EGFR-mutated tumors [2].
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Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182, Butyric Acid from Probiotic Staphyloco...
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Vol.48 No.2 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1S2Z7n2 via IFTTT
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Sensory Topography of Oral Structures. JAMA Otolaryngol Head Neck Surg. 2016 Sep 29; Authors: Bearelly S, Cheung SW Abstract Import...
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