Human passive cutaneous anaphylaxis in the 21st century: Worth the risk?

“In 1921, Otto Carl W. Prausnitz (Giles) (1876-1963) identified what was later called ‘reagin,’ now known to be immunoglobulin E (IgE) antibody, found in higher quantities in the serum of allergic individuals than in nonallergic individuals. Prausnitz and his colleague, Heinz Küstner (1897-1963), discovered that a serum factor from an allergic patient (Küstner) could transfer skin-sensitizing properties to another individual (Prausnitz). Twenty-four hours after injecting serum from Küstner, who was allergic to fish, into Prausnitz's skin, they injected fish extract into the same area.

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