Genetic alterations in TRAF3 and CYLD that regulate nuclear factor κB and interferon signaling define head and neck cancer subsets harboring human papillomavirus

Recent genomic studies of head and neck squamous cell carcinoma by The Cancer Genome Atlas as well as other groups identified deletions or mutations in tumor necrosis factor receptor-associated factor 3 (TRAF3) and cylindromatosis lysine 63 deubiquitinase (CYLD) that previously were implicated in nuclear factor-κB (NF-κB) and antiviral interferon responses. In this issue, Hajek et al find genomic alterations in TRAF3/CYLD define distinct subsets of human papillomavirus-positive head and neck squamous cell carcinomas with associated activation of transcription factor NF-κB, episomal human papillomavirus infection of tumors, and improved patient survival. See also pages 000-000.

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