Publication date: April 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 95
Author(s): İbrahim Ağrı, Arzu Erdal Ağrı, Mehmet Eser Sancaktar, Asude Ünal, Erkan Can, Mustafa Bakırtaş, Fatih Yılmaz, Mehmet Derya Demirağ, Recep Ünal
ObjectiveTo investigate the effects of caffeic acid phenethyl ester (CAPE) on tympanosclerosis.Materials and methodsThirty-two male Sprague Dawley rats were separated into 4 groups as CAPE (n = 10), alcohol (n = 10), control (n = 8) and normal (n = 4) groups. All tympanic membranes except normal group were myringotomised and type 3 Streptococcus pneumoniae strains was injected into their middle ears. Myringotomies were repeated for 5 weeks. Intraperitoneal (i.p) CAPE were administrated to the CAPE group at 10 μmol/kg/day and 10% ethyl alcohol administrated to the alcohol group for 5 weeks. The control group were left untreated. Findings of myringosclerosis were recorded by otomicroscope at sixth week. Then, all rats were sacrificed and tympanic membrane thickness and severity of middle ear mucosal inflammation evaluated histopathalogically.ResultsSeverity of myringosclerosis was significantly higher in the alcohol and control groups compared to the CAPE group (p < 0.001), but was not significant when alcohol and control groups were compared (p = 0.17). The tympanic membrane thickness measured in the alcohol and control groups were significantly higher compared to the CAPE group (p < 0.001), but was not significant when alcohol and control groups were compared (p = 0.17). The severity of inflammation in the middle ear mucosa was significantly higher in the alcohol and control groups compared to the CAPE group (respectively, p < 0.001, p = 0.03). The severity of inflammation in the middle ear mucosa was not significant between alcohol and control groups (p = 0.30).ConclusionCAPE has anti-inflammatory and antioxidant effects on the development of MS in myringotomized rats, so reduces the severity of tympanosclerosis.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2lCC5sF
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Abstract BACE1 is an indispensable enzyme for generating β-amyloid peptides, which are excessively accumulated in brains of Alzheimer'...
-
Publication date: Available online 23 April 2017 Source: Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Yu-Jen Chiu...
-
Objective To identify the injury history features reported by patients with anterior cruciate ligament (ACL) injuries and determine whether ...
-
Rhinoplasty is perhaps the most challenging and elegant procedure within all of plastic surgery. In this issue of JAMA Facial Plastic Surger...
-
Science Daily Scientists develop light-controllable tool to study CaMKII kinetics in learning and memory Science Daily In summary, t...
-
AMEDEO Otorhinolaryngologyhttp://www.amedeo.comhttp://m.amedeo.com2019-10-07Your Personal Amedeo Web... AMEDEO Otorhinolaryngologyhttp://www...
-
Publication date: October 2017 Source: International Journal of Biological Macromolecules, Volume 103 Author(s): Sapna, Bijender Singh A...
-
This Viewpoint discusses variances in cardiovascular prevention guidelines from the United States, Europe, and Canada and the debate surroun...
-
Three-Dimensional Printing and Its Applications in Otorhinolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg. 2016 Nov 01;...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου