Δευτέρα 13 Φεβρουαρίου 2017

MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats

<span class="paragraphSection">Post-publication, the authors discovered a scale factor error of 5 affecting volumetric readings from the whole-body plethysmography chamber used for juvenile male rats (PND 21-28) in this study (Buxco PLY3211). As such, reported tidal volume (TV) and minute ventilation (MV) data are erroneously high for this group. This change does not affect the interpretation of this data as the scale factor change is applicable to both groups being compared. The below figure shows the corrected graphical representation of juvenile male rats' TV and MV readings (Fig. 8F and G). All numerical values have been reduced by a factor of 5 to correct for the recognized instrument error. The text of the results section has been updated online to reflect this numerical correction and should be as follows: <strong><span style="font-style:italic;">Mecp2</span><sup>ZFNΔ/y</sup> rats display respiratory abnormalities early in development.</strong></span>

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