Folate-mediated chemotherapy and diagnostics: An updated review and outlook

Publication date: Available online 22 February 2017
Source:Journal of Controlled Release
Author(s): Leyuan Xu, Qianming Bai, Xin Zhang, Hu Yang
Folate receptor (FR) is highly expressed in many types of human cancers compared to normal cells, and it has been actively studied for developing targeted chemotherapy. Tremendous efforts have been made in developing FR-targeted nanomedicines and translating them into clinical applications. This article provides a concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy and diagnostics with an emphasis on in vivo applications. The cellular uptake mechanisms, pharmacokinetics (PK), administration routes and major challenges in FR-targeted nanoparticles are discussed.

Graphical abstract

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