Τρίτη 21 Φεβρουαρίου 2017

Estrogen receptor {alpha} wields treatment-specific enhancers between morphologically similar endometrial tumors [Applied Biological Sciences]

The DNA-binding sites of estrogen receptor α (ERα) show great plasticity under the control of hormones and endocrine therapy. Tamoxifen is a widely applied therapy in breast cancer that affects ERα interactions with coregulators and shifts the DNA-binding signature of ERα upon prolonged exposure in breast cancer. Although tamoxifen inhibits...

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